NUE Epic 100 Mile Race Series
| Race | Date | Location | Limit | Reg. Opens | ||
| 1. True Grit Epic | 11-13 Mar | Santa Clara, UT | 1200 | OPEN | ||
| 2. Cohutta 100 |
23 April |
Ducktown, TN | 500 | 1/15/2022 | ||
| 3. Mohican MTB100 | 21 May | Loudonville, OH | 600 | 1/1/2022 | ||
| 4. High Cascades 100 | 16-Jul | Bend, OR | 350 | OPEN | ||
| 5. Wilderness 101 | 23 July | State College, PA | 350 | 11/15/2021 | ||
| 6. Telluride 100 | 30 July | Telluride, CO | 300 | OPEN | ||
| 7. Shenandoah 100 | 4-Sep | Harrisonburg, VA | 650 | 11/15/2021 | ||
| 8. Marji Gesick 100 | 17 -Sept | Ishpeming, MI | 666 | OPEN | ||
| 9. Big Bear Grizzly 100 | 8-Oct | Big Bear Lake, CA | 500 | 1/1/2022 |
